Abstract
A study aimed to examine immunomodulatory effect of concentrated cell free filtrate (CCF) of Lactobacillus acidophilus on immune system of mice by detecting the total and absolute counts of leucocytes. It was shown that CCF of Lactobacillus acidophilus caused a significant increase in total leucocyte count for all concentrations used in comparison with negative control. However, in absolute leucocyte counts the, CCF of L.acidophilus at doses (500 , 750) mg/kg caused a significant increased in lymphocyte, neutrophil and monocyte counts, while there was no significant differences in eosinophils and basophil cells number of mice treated with bacterial filtrate. The interaction study showed that the post-treatment with CCF of L. acidophilus caused a significant increase in total leucocytes count and absolute counts of all types of leucocyte cells except basophils and esinophils which showed no significant differences in comparison with pre-treatment
Highlights
A study aimed to examine immunomodulatory effect of concentrated cell free filtrate (CCF) of Lactobacillus acidophilus on immune system of mice by detecting the total and absolute counts of leucocytes
The criterion for selection of the ideal dose was based on the approximation between the values of total leucocytes count in the animals treated with CCF of L. acidophilus and the negative control
66.5±88.3 a Discussion The results demonstrated that a treatment with Lactobacillus acidophilus concentrated filtrate had a significant effect on total and differential leucocytes count especially with the lymphocyte and neutrophils, which both showed a significant increase in their count
Summary
A study aimed to examine immunomodulatory effect of concentrated cell free filtrate (CCF) of Lactobacillus acidophilus on immune system of mice by detecting the total and absolute counts of leucocytes. In our study the immunomodulatory effects of LAB has been explored on mice blood cell following treatment with concentrated cell free filtrate (CCF) of Lactobacillus acidophilus. Three doses of L. acidophilus concentrated filtrate (250, 500, and 750) mg/kg were prepared to assess the immunological effects of cell free supernatant extracts in modulating the effects of the drug cyclophosphomide in albino male mice.
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