Abstract
ABSTRACTBackground: Sepsis is a potentially life-threatening complication of an infection that occurs when chemicals released into the bloodstream to fight the infection trigger inflammatory responses throughout the body, especially in the acute phase of the disease, producing excessive pro-inflammatory cytokines, leading to multiple organ injury and death. The Hev b 13 fraction has demonstrated biological activity capable of inducing IL-10 production and shrinking inflammatory disease lesions. Aim: To investigate the immunomodulating effects of the Hev b 13 fraction on septic rats. Methods: Acinetobacter baumannii was injected into the peritoneal cavity of the animals after sustaining a lesion in the pancreas, with the stomach as an entry point. After 10 h of infection, they were euthanized for blood and lung collection, followed by total and differential leukocyte count, determination of cytokine level and histopathological analysis. Results: Administering a single dose of the Hev b 13 fraction 2 h after sepsis induction significantly decreased total leukocyte count. Higher IL-10 and IL-4 and lower IL-6 production shrank the lung tissue lesions compared to the control groups. Conclusion: The Hev b 13 fraction exhibits an anti-inflammatory tendency, with potential for sepsis treatment.
Highlights
The definition of sepsis covers situations in which the systemic inflammatory response syndrome triggered by suspected or confirmed infection is established
Resistance profile of Acinetobacter baumannii strains The analysis of the antimicrobial resistance profile of Acinetobacter baumannii strains used in the induction of sepsis is shown in Table 1, being resistant to 14 different types of antibiotics and sensitive only to tetracycline and trimetropim
Laboratory analysis of leukocytes and platelets In the comparison between the means of the laboratory tests of white series and platelets, the total leukocyte count was significantly lower (p
Summary
The definition of sepsis covers situations in which the systemic inflammatory response syndrome triggered by suspected or confirmed infection is established. Its clinical manifestations - such as fever, edema, hypercoagulation, tachypnea and peripheral hypotension - derive from the systemic release of inflammatory mediators, called cytokines, by the defense and endothelial cells, playing an important role acting as chemical messengers[2,3]. There are still those who characterize sepsis as the rupture of the complex balance between pro-inflammatory and anti-inflammatory cytokines[10]. Recent research using a protein derived from Hevea brasiliensis (rubber tree) natural latex, called Hev b 13, has demonstrated biological activity capable of inducing the production
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