Abstract
Long chain polyunsaturated fatty acids (PUFAs) are well-known for their beneficial immunomodulatory effects in a variety of autoimmune and inflammatory disorders. The underlying molecular mechanisms are manifold, but are still elusive to a large extent. Several cell types are target of PUFA action. In this chapter, the effects of PUFAs on T-cell activation and function are discussed. PUFAs directly affect T-cell signaling and thus activation as well as T-cell interactions with antigenpresenting cells (APCs). The mainstream of publications in the field describes alterations of the lateral membrane organization as crucial for PUFA action on T-cells. Therefore, this chapter includes a brief overview over the current understanding of membrane microdomains, so-called “lipid rafts,” and their role in T-cell signal transduction.
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