Abstract

Immunologic Development: Introductory Remarks.- T-Cell Development.- Humoral Immunity in the Human Neonate.- Regulation of Antibody Synthesis in the Neonate.- The Ontogeny of the Immune Response: The Role of Maternal Factors.- Mononuclear Phagocyte Function in the Perinatal Period.- Mechanisms of Abnormal Neutrophil Function in the Human Neonate: Prospects for Therapy.- Complement Function in the Neonate.- Modulation of Nonspecific Defense Mechanisms in the Neonate.- T-Cell Development and Function: Relationship to Immunodeficiencies.- Activation and Functional Capacity of Neonatal T Cells: Analysis of Interleukin-2 and Interleukin-2 Receptor Responsiveness.- Development of Lymphocyte Responses to Herpes Simplex Virus Following Neonatal Infection.- T and NK Lymphocyte Subpopulations in the Neonate.- Analysis of the Immunological Dysregulation Underlying Defective Interferon ? Secretion in the Human Neonate.- Immunity and Infections in the Neonate.- Intravenous Gammaglobulin Replacement for Prophylaxis of Infection in Preterm Neonates.- Prevention of Atopy: Neonatal Aspects.- Treatment of Infants with Severe Combined Immunodeficiency by Bone Marrow or Fetal Liver Transplantation.- Summing Up.

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