Abstract
Soft tissue trauma of skeletal muscle is one of the most common side effects in surgery. Muscle injuries are not only caused by accident-related injuries but can also be of an iatrogenic nature as they occur during surgical interventions when the anatomical region of interest is exposed. If the extent of trauma surpasses the intrinsic regenerative capacities, signs of fatty degeneration and formation of fibrotic scar tissue can occur, and, consequentially, muscle function deteriorates or is diminished. Despite research efforts to investigate the physiological healing cascade following trauma, our understanding of the early onset of healing and how it potentially determines success or failure is still only fragmentary. This review focuses on the initial physiological pathways following skeletal muscle trauma in comparison to bone and tendon trauma and what conclusions can be drawn from new scientific insights for the development of novel therapeutic strategies. Strategies to support regeneration of muscle tissue after injury are scarce, even though muscle trauma has a high incidence. Based on tissue specific differences, possible clinical treatment options such as local immune-modulatory and cell therapeutic approaches are suggested that aim to support the endogenous regenerative potential of injured muscle tissues.
Highlights
Skeletal muscle belongs to the largest organ system in the human body, accounting for one-third of body weight [1]
The gluteus medius muscle is frequently damaged during total hip arthroplasty, which can lead to joint dislocation as well as pelvitrochanteric insufficiency and to poor function and patient-reported long-term outcome scores [8,9]
If the extent of the injury exceeds the regenerative capacity of the tissue, it results in a loss of contractile muscle tissue and the development of fibrosis
Summary
Skeletal muscle belongs to the largest organ system in the human body, accounting for one-third of body weight [1]. It has been shown that the skeletal muscles of the pelvic and spinal column are significantly impaired in its function even when minimally invasive interventions with smaller incisions and a limited exposition of the surgical field were performed [12,13]. Despite this ubiquitous problem, there is currently no causative treatment available for either sport-related or iatrogenic skeletal muscle injuries
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
