IMMUNOLOGICAL VALUE POST HEPATITIS B IMMUNIZATION IN CHILDREN AGED 12-24 MONTHS IN BENGKULU CITY IN 2019

Abstract

Hepatitis is a health problem in the world, including Indonesia. The hepatitis B virus has infected 2 billion people in the world, about 240 million of whom have chronic hepatitis B. As many as 1.5 million people die each year due to hepatitis. Indonesia is a country with the second largest hepatitis B high endemicity in the South East Asian Region (SEAR) after Myanmar. According to the 2013 Rikesdas , the prevalence of hepatitis is 1.2% of the population in Indonesia, of which 1-5% are pregnant women with hepatitis B virus. To determine the post-immunization immunological results in children 12-24 months in the city of Bengkulu in 2019 by comparing the first immunization, birth weight and completeness of immunization. This study is a laboratory study with respondents aged 12-24 months who are post-Hepatitis B immunization, samples were taken as many as 40 children who were post-Hepatitis B immunization. Samples were examined for HBs Ab against hepatitis B in the Clinical Laboratory of RSUD Bekasi, West Java. then analyzed using independent t-test. Protective immunity was obtained by 57.5% with an average titer of 76.144 m IU/ml for anal 12-24 months in Bengkulu city in 2019. And there was an effect between the first administration of immunization > 7 days, birth weight <2500 grams and completeness of immunization for the formation of antibodies against Hepatitis B It is hoped that the Bengkulu city health office can increase the coverage of hepatitis B immunization, especially for HB0, as well as evaluate the implementation of immunization.