Abstract
Male Swiss Webster mice were fed the organophosphate pesticide, leptophos, in feed at concentrations of 0, 10, 100, and 500 ppm for 12 weeks. Signs of organophosphate poisoning were moderate to severe inhibition of serum cholinesterase and decreased body weight gains of leptophos-exposed mice. Primary and secondary immune responses as measured by hemolytic plaque assay of antibody forming cells were not significantly altered in mice receiving leptophos compared to the controls. Histologically, lesions were not observed in mice which consumed as much as 170 mg leptophos/kg body weight/day for 12 weeks. It is concluded that leptophos does not significantly affect antibody formation and that this pesticide is only slightly toxic to mice.
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