Abstract
Rats infected with 5000 Nippostrongylus brasiliensis larvae each, lose the infection almost completely in 20 days. This “self-cure” is due to an immune response on the part of the host. By transferring adult worms surgically to passively immunized and to normal rats, it has been shown that humoral antibody is important in interfering with the establishment of the parasites. Protective serum has no immediate lethal effect on N. brasiliensis in vitro nor does it immediately inhibit O 2 uptake of the adult parasite when measured by Warburg's Direct Method. With the aid of Cr 51 labeled erythrocytes, it has been shown that N. brasiliensis does not consume whole blood in any significant quantity. It is considered that antibody, against the parasite, may be protective because of its role in local anaphylaxis rather than direct actions on the worms.
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