Abstract
The responses of in vitro spleen cells to phytohemagglutinin (PHA), concanavalin A (Con A), pokeweed mitogen (PWM) and lipopolysaccharide (LPS) were studied in mice with herpes simplex virus (HSV) infection of the cornea. For 1 week after corneal inoculation of HSV, the responses of spleen cells from mice infected with HSV to PWM and LPS were comparable to those from normal mice, but the responses to Con A and PHA were lower. These results suggest that in acute herpetic keratitis in mice, the responses of T 6cells are more markedly suppressed than those of B cells.
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