Abstract
The ability of a hyperimmune antiserum to NIH ovine LH to inhibit HCG, PMSG and ovine LH was compared, and the effect of absorption of this antiserum with heterologous gonadotropins on the neutralization of LH was studied. Titration of the inhibitory capacity of the antiserum was done primarily by adaptation for antiserum assay of the test for ovarian ascorbic acid depletion in rats primed with PMSG and HCG, supplemented in part by ventral prostate weight method using hypophysectomized male rats. When inhibition of the depletion of ascorbic acid from the ovary was the basis for comparison, the amount of antiserum required to inhibit ovine LH and PMSG was nearly the same, but 60 to 30 times as much was necessary for inhibition of HCG activity. Absorption of the antiserum with ovine FSH or HCG did not significantly alter the LH neutralization titer of the antiserum, but experiments with antiserum absorbed with PMSG failed to give conclusive results, due to excess PMSG in the absorbed serum which was impossi...
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