Abstract
An antivenom was prepared for Buthus minax venom by hyper-immunizing rabbits. The antivenom protected the rats against the hypertensive effect of the venom but it did not prevent the respiratory arrest. The antivenom also protected the rats against several times the lethal dose. In mice the antivenom completely protected the animals against doses of the venom equal to the ld 50 but no such protection was achieved when doses equal to 5 times the ld 50 were injected. Using the immunodiffusion and immunoelectrophoresis techniques, four precipitin bands were revealed with B. minax venom but only one band was formed with Leiurus quinquestriatus venom and it was not identical with any of the bands formed with B. minax. A cross-reaction occurred between the band formed with L. quinquestriatus venom and one of the bands formed with B. minax venom. The antivenom did not prevent the hypertensive or the lethal actions of L. quinquestriatus venom. In view of the abundance of B. minax in the Sudan and other neighbouring countries and the absence of an antivenom for B. minax in the polyvalent antiscorpion venoms, it is suggested that the B. minax antivenom ought to be included in the polyvalent scorpion antivenin.
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