Abstract
Summary Immunized and nonimmunized guinea pigs, rats and mice given graded challenge doses of Bacillus anthracis spores were compared. The reciprocal of time-to-death was found to be linearly related to log10 challenge dose over a reasonable range of doses, and, therefore, a difference in position of the parallel regression lines represented a difference in response of control and immunized animals. This difference in position of regression lines is the log increase in dose required to cause the immunized group to give the same response as the control. This log increase is called the mean Immunity Index. The mean index of an immunized population of guinea pigs was 3.2. The distribution of individuals in the control and immunized groups overlapped and thus it was concluded the variability of response of immunized guinea pigs was greater than the control animals, and that only 46% of the immunized population had a significant protection against B. anthracis challenge.
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