Abstract
Cellular immunity was studied in 15 patients with bullous pemphigoid before treatment, and in 7 after remissions obtained by corticosteroid and plasma exchange. Before treatment the lymphocyte subpopulations (assessed by E-rosetting, immunofluorescence and monoclonal antibodies) showed a decrease of total T cells and CD8 cells, and an increase of B cells, when compared with controls. Mitogenic responses to PHA, Con A, and PWM were in the normal range. After treatment, no modification in lymphocyte subpopulations or in mitogenic responses was found. Plasma exchange, an effective treatment for bullous pemphigoid, does not act by modifying cellular immunity but probably by improving abnormal reticuloendothelial function.
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