Abstract
Overheating of mice over the course of 10 and 20 days suppresses the proliferative activity of splenic cells in response to stimulation with phytohemagglutinin, concanavalin A, lipopolysaccharide, pokeweed mitogen, and alloantigens. The number of antibody-producing cells in the spleen drops on day 5 of overheating and is still low on days 10–20. Forty days after the start of overheating the functional activity of lymphocytes is restored. Overheating of animals does not change the colony-forming activity of hemopoietic stem cells.
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