Abstract
Polyclonal rabbit antisera were raised against ten snake phospholipase A 2 neurotoxins and one snake phospholipase A 2 cytotoxin. Immunological cross-reactivities between these toxins, two other snake phospholipase A 2 enzymes and pancreatic phospholipase A 2 were studied using ELISA technology. All snake phospholipase A 2 neurotoxins fell into two main antigenic classes. One antigenic class was composed of all the elapid toxins tested (textilotoxin, taipoxin, notexin, pseudexin and β-bungarotoxin), the cytotoxic phospholipase A 2 from Naja naja atra and pancreatic phospholipase A 2. β-Bungarotoxin seemed to be in an immunological subclass of its own compared to the rest of the elapid toxins. The second antigenic class was comprised of crotalid and viperid phospholipase A 2 neurotoxins (crotoxin, concolor toxin, Mojave toxin, vegrandis toxin, ammodytoxin and caudoxin). Our data indicated that the viperid toxins, caudoxin and ammodytoxin, were an immunological subclass apart from the crotalid toxins.
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