Abstract
By separating FcR + and FcR − cells from stimulator spleens using an EA rosetting procedure, it was found that EA-rosetting (FcR +) cells stimulate mixed-lymphocyte culture reaction (MLR) far more effectively than do non-EA-rosetting (FcR −) cells. The difference in stimulatory activity is observed in MLR of both H-2 and M-locus different combinations and cannot be explained by the proportion of B cells and macrophages contained in each population. The finding that FcR + cells can stimulate allogeneic responding T cells more effectively than FcR − cells suggests a close association of FcR with Ia and Mls antigens on the cell surface.
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