Immunological NBT Test – Indicator of Phagocytic and Metabolic Activity of Neutrophilic Granulocytes in Complications of Ent Organs Diseases

Zarema N Lovpache,Arthur M Baziev,Tamara G Tlupova,Diana A Teuvazhukova,Aslan A Teuvov

doi:10.13005/bpj/1361

Zarema N Lovpache, Arthur M Baziev + Show 3 more

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https://doi.org/10.13005/bpj/1361

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Abstract

Infectious diseases associated with diseases of ENT organs are quite common. Therefore, this problem requires detailed study. The main goal of the work is to characterize the immunological NBT test – the index of phagocytic and metabolic activity of neutrophilic granulocytes in cases of complications of ENT diseases. To achieve this goal and study the problem in detail, the authors used experimental methods. The experiment was conducted on 40 patients from 32 to 65 years. The authors found that during the eruptive phase of the disease, the percentage of NBT positive granulocytes and tetrazolium activity significantly increased and amounted to 30-40%, while the control group’s data were the following – the activity of the NBT test was 4.9-6.8%. It was also found that the NBT test in patients with otitic meningitis was 26-62%, while in all patients with serous meningitis, the level of the NBT test was low – 6-11.

Highlights

The threshold of bacterial infections in various regions of the Russian Federation in recent years is characterized by a high percentage, up to 80% of the total number of patients
Our studies to determine the value of the NBT test in bacterial infections, especially their rhinogenous complications showed that during the eruptive phase of the disease the percentage of NBT positive granulocytes and tetrazolium activity significantly increased and amounted to 30- 40%, while the control group data were as follows – the activity of the NBT test is 4.9-6.8%
The cause of increased values of the NBT test in the early recovery stage with staphylococcal sinusitis, otitis media can be related to the circulation of immune complexes in the blood

Summary

Introduction

The threshold of bacterial infections in various regions of the Russian Federation in recent years is characterized by a high percentage, up to 80% of the total number of patients. Often patients began to seek treatment already with a complicated course of bacterial infections, which is associated with frequent self-medication and irrational administration of antibiotics. Proceeding from this, as a rule, there are such complications as prolonged sinusitis, otitis media, otogenous meningitis, orbital cellulitis. The study of the functional and metabolic.

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