Abstract
The cerebral palsy is highly actual issue of pediatrics, causing significant neurological disability. Though the great progress in the neuroscience has been recently achieved, the pathogenesis of cerebral palsyis still poorly understood. In this work we reviewed available experimental and clinical data concerning the role of immunocompetent cells in pathogenesis of cerebral palsy. Maintaining of homeostasis in nervous tissue and its transformation in case of periventricular leukomalacia were analyzed. The reviewed data demonstrate involvement of immune regulatory cells in the formation of nervous tissue imbalance and chronicity of inborn brain damage. The supported opinion, that periventricular leukomalacia is not a static phenomenon, but developing process, encourages us optimism about possibility of its correction. The further study of changes of the nervous and immune systems in cerebral palsy will contribute to creating fundamentally new directions of the specific therapy and individual schemes of rehabilitation.
Highlights
The cerebral palsy is highly actual issue of pediatrics, causing significant neurological disability
In this work we reviewed available experimental and clinical data concerning the role of immunocompetent cells in pathogenesis of cerebral palsy
Идентификация морфологических и биохимических маркеров апоптоза и показателей, характеризующих иммунорегуляцию тканевого гомеостаза в нервной ткани, должна в перспективе способствовать более глубокому пониманию механизмов этиопатогенеза заболеваний, улучшению диагностики и созданию новых направлений этиопатогенетической терапии и разработке индивидуальных схем реабилитации больных Детский церебральный паралич (ДЦП)
Summary
The cerebral palsy is highly actual issue of pediatrics, causing significant neurological disability. В этой работе мы проанализировали экспериментальные и клинические данные касающиеся роли иммунокомпетентных клеток в регуляции тканевого гомеостаза в нервной ткани в норме и в случае перивентрикулярной лейкомаляции.
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