Immunological functions of complement system involved in evolution of ovarian clear cell carcinoma discovered by the gene ontology-based immunofunctionome analysis

C.C Chang

doi:10.1016/j.ygyno.2020.05.230

Immunological functions of complement system involved in evolution of ovarian clear cell carcinoma discovered by the gene ontology-based immunofunctionome analysis

C.C Chang

https://doi.org/10.1016/j.ygyno.2020.05.230

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Journal: Gynecologic Oncology

Publication Date: Oct 1, 2020

#Ovarian Clear Cell Carcinoma #Subtypes Of Epithelial Ovarian Carcinoma + Show 8 more

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Abstract

Objective: Ovarian clear cell carcinoma (OCCC) is the second most common among the four subtypes of epithelial ovarian carcinoma (EOC), especially in Asia, and refractory to chemotherapy is accompanied with worse prognosis after the preliminary optimal debulking operation. OCCC may evolve from endometriosis, a chronic immune-related disease, and immunotherapy seems to be a potential alternative solution for OCCC. This study investigated the whole picture of immunological functions of OCCC during disease progression.

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