Immunological Features and Clinical Benefits of Conjugate Vaccines against Bacteria.

Paolo Durando,Saul N Faust,Antoni Torres

doi:10.1155/2015/934504

Abstract

Immunological Features and Clinical Benefits of Conjugate Vaccines against Bacteria.

Highlights

Bacteria such as Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae are important pathogens that cause invasive and noninvasive diseases with a still high burden in terms of both morbidity and mortality worldwide [1,2,3,4]
The acquisition of this knowledge is of particular importance for public health policy makers, in order to establish new vaccines into clinical practice using welldesigned immunization strategies
First generation vaccines were based on bacterial capsular polysaccharides; yet, most of these antigens are considered Tindependent antigens, showing significant gaps in terms of immunogenicity, with respect to the generation of the immune memory [5,6,7]

Summary

Introduction

Bacteria such as Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae are important pathogens that cause invasive and noninvasive diseases with a still high burden in terms of both morbidity and mortality worldwide [1,2,3,4]. The acquisition of this knowledge is of particular importance for public health policy makers, in order to establish new vaccines into clinical practice using welldesigned immunization strategies.

Results

Conclusion