Abstract
According to modern concepts, chronic gastritis is a group of phenotypically similar diseases, the basis of which is the lesion of the gastric mucosa of different genesis and different regeneration potential. Of particular interest is the group of patients (children in the presented article) in whom gastric mucosa lesions are associated with the current infectious process caused by a combination of two causative factors - Helicobacter pylori (H. pylori) and Epstein-Barr virus (EBV). The data obtained as a result of the study of cellular and humoral immunity, autoimmunity and interferon system show significant disorders of immunological reactivity in children with chronic gastritis associated with H. pylori and VEB. The imbalance of T-lymphocyte subpopulations, impaired function of B-lymphocytes, dysimmunoglobulinemia and pronounced imbalance of interferon system with a significant decrease in induced synthesis of IFN-α and IFN-γ by blood leukocytes were revealed. The suppressive effect of VEB on various links of immunity was proved, which necessitates immunocorrective treatment. The results of the study may indicate the trigger role of VEB in the development of autoimmune gastritis.
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