Abstract
Background: The Quantiferon-CMV assay is a test for Cell Mediated Immune (CMI) responses to peptide antigens that simulate CMV proteins. Individuals infected with CMV usually have CD8+ lymphocytes in their blood that recognize these antigens. This recognition process involves the generation and secretion of the cytokine and interferon (IFN). The detection and subsequent quantification of IFN forms the basis of this test. Supplement: Abstracts of the Tenth International Congress on Drug Therapy in HIV Infection http://www.biomedcentral.com/content/pdf/1758-2652-13-S4-info.pdf Conference: Tenth International Congress on Drug Therapy in HIV Infection 7-11 November 2010 Glasgow, UK (Published: 8 November 2010) doi:10.1186/1758-2652-13-S4-P192 Cite this article as: Dumitru et al.: Immunological diagnosis of CMV infection in HIV-infected patients. Journal of the International AIDS Society 2010 13(Suppl 4):P192. Full text: PubMed Central: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3112974/
Highlights
The Quantiferon-CMV assay is a test for Cell Mediated Immune (CMI) responses to peptide antigens that simulate CMV proteins
IgM ELISA was negative in all cases, IgG ELISA was positive in 45 patients (95.5%) and Quantiferon-CMV assay was reactive in 38 cases (79.1%)
The patients who were treated with gancyclovir for CMV retinitis showed positive ELISA IgG, but negative Quantiferon-CMV assay
Summary
The Quantiferon-CMV assay is a test for Cell Mediated Immune (CMI) responses to peptide antigens that simulate CMV proteins. Individuals infected with CMV usually have CD8+ lymphocytes in their blood that recognize these antigens. This recognition process involves the generation and secretion of the cytokine and interferon (IFN). The detection and subsequent quantification of IFN forms the basis of this test. Purpose of the study To evaluate the accuracy of Quantiferon-CMV assay in diagnosis of CMV infection in HIV positive patients and compare it with older ELISA method
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