Abstract
This study highlights risk factors for CD4 cell losses and clinical consequences of antiretroviral treatment interruptions. The largest decreases in CD4 cell counts occur in patients with lower nadir CD4 cell counts or more advanced disease. Falls are greater in those with higher rates of CD4 cell loss before highly active antiretroviral therapy, and are associated with a significant increase in clinical/AIDS events during treatment interruption. Caution is therefore advised when considering treatment interruption in those with advanced disease.
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