Abstract

Summary: Results in 377 couples indicate that the sperm immobilization test provides a reliable means of detecting significant humoral anti‐sperm activity in infertile patients. Occlusion therapy in patients with sperm antibodies has proved disappointing when compared with the natural reproductive pattern in untreated patients.A continuing prospective study indicates a lower subsequent fertility rate, and a markedly higher abortion rate, in women with sperm antibodies compared with those without them. Notwithstanding this, patients with infertility of 3 or more years' duration achieved a subsequent pregnancy rate of 27%, even in the presence of sperm antibodies. The nature and significance of sperm iso‐immuniza‐tion requires much further elucidation.

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