Abstract
A parallel study was made of the level of immunologic reactivity and the state of adrenocortical function in BALB/c mice 7 days after a single injection of various doses of methylcholanthrene. Definite correlation was found between the degree of immunodepression induced by different doses of methylcholanthrene and determined as the number of antibody-forming cells in the spleen of the experimental mice and the 11-hydroxycorticosteroid concentration (both free and bound) in the blood plasma of the mice 7 days after injection of the carcinogen. These results may indicate that adrenocortical hormones play an important role in the pathogenesis of immunodepression induced by a chemical carcinogen.
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