Abstract
Summary The antigens determined by individual histocompatibility genes differ in ability to induce transplantation immunity. Those of the H-2 locus are effective in all tissues of an individual and induce immunity rapidly. Those of the H-3 locus are antigenically less effective in some tissues than in others and permit longer graft survival. Using coisogenic strains of mice a further comparison has been made between antigens of H-2 and H-3 genes with respect to: a) the time required to induce immunity, b) the time when immunity can first be demonstrated, c) the effect of variations in graft dose, and d) adoptive transfer of immunity with lymph node and spleen cells. It was found that in both H-2 and H-3 strains immunity can be induced by 4 days contact with a skin graft but that additional time must elapse before immunity can be demonstrated. This additional time requirement was greater in H-3 than in H-2. The effects of variations in graft dose were equivalent and minimal. H-2 immunity was adoptively transferred by lymph nodes and spleen cells. H-3 was transferred best by nodes that had been exposed to skin grafts for 24 days. Nodes that were stimulated by H-2 and H-3 antigens from the same grafts transferred immunity against H-2 only.
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