Abstract
SummaryThe plasma of a patient with acute monomyelogenous leukemia when used as an antigen in Ouchterlony tests reacted with hamster serum containing anti-avian leukosis group-specific antibodies. Of the two immunoprecipitin bands seen, one merged in a reaction of identity with a band formed by AMV and the antibody-containing hamster serum. Since the leukemic plasma did not react with normal hamster serum, normal chicken plasma or anti-normal chicken serum in immunodiffusion tests, the results of this study represent a true cross reaction between antigens from a human leukemic source and antibodies directed against the avian leukosis group-specific antigens. Electron microscope studies on the human plasma revealed viruslike particles in a concentration greater than 5 × 107 particles/ml based upon direct counts. As yet the data do not allow for any correlations to be made between the immunologic findings and the presence of virus-like particles in the plasma.
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