Abstract
A comparative study was made of the effect of anti-bee venom phospholipase A 2 serum and antir-bald face hornet venom serum on the activity of phospholipase A 2 present in yellow hornet, yellow jacket, bald face hornet, and honeybee venoms. Activity of phospholipase A 2 present in the venoms was measured titrimetrically using egg yolk dispersion as the substrate. Antiserum against pure bee venom phospholipase A 2 activity completely suppressed bee venom phospholipase A 2 activity but failed to inhibit phospholipase A 2 activity in yellow jacket, yellow hornet, and bald face hornet venoms. Anti-bald face hornet venom serum suppressed the activity of phospholipase A 2 present in the four insect venoms with the inhibitory effect decreasing in the order: bald face hornet > yellow hornet > yellow jacket > honeybee. A combination of immunoelectrophoresis and immunodiffusion techniques gave indication of common antigenic sites in a component of yellow hornet venom and a component of bald face hornet venom. The results suggest that IgG antibodies against pure bee venom phospholipase A 2 may not give any protection against the reaction(s) due to the phospholipase A 2 in yellow hornet, yellow jacket, and bald face hornet venoms, while antibodies against bald face hornet venom phospholipase A 2 may give some cross-protection.
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