Immunologic and cerebrovascular reactivity relationships in patients with initial manifestations of chronic cerebral ischemia

Abstract

Introduction. The influence of cardiovascular risk factors has a long asymptomatic course, since the vessels are the main target body. Functionally and structurally restructuring of vessels mainly target bodies in terms of the most supple period is like prevention of irreversible changes in organs and tissues and the development of cardiovascular events. We conducted a study whose purpose was to investigate the presence and assessment of the nature of relationships between indicators immunoreactivity to structural components of cardiovascular and cerebrovascular reactivity in carotid and vertebral-basilar basins in response to the multidirectional metabolic and myogenic stimuli in patients with initial manifestations of chronic cerebral ischemia (ChCI). Material and methods. We have examined 55 people of middle age 51,3 ± 7,0 years with initial manifestations of the ChCI. All patients performed general clinical, clinical-neurological, clinical and instrumental and clinical laboratory tests. The level of auto antibodies (auto AB) antigens to platelets, cardiomyocytes and vascular endothelial serum of patients was determined by the method Poletayeva O.B. (Russia). Indicators of cerebrovascular reactivity (CVR) received during trans cranial ultrasound scan using multidirectional metabolic and myogenic functional stress stimulus (FSS). Results and discussion. There was a statistically significant association between (index of reactivity) IR infringement in response to hyperkapnia trial in carotid basin and a deviation of up to autoAB NOS (X 2 (1) = 3.6 ; VKramer = 0.354, p = 0.05) and plasminogen / angiostatin (X 2 (1) = 6.22; VKramer = 0.463, p = 0.013). It was found association between IR deviation in response to hypokapnia trial in carotid basin and a deviation of autoAB to rheumatoid factor (X 2 (1) = 7.03; VKramer = 0.493, p =0.008, Fisher's exact test = 0.016) and the association between deviation IR hypokapnia on trial in carotid pool and adeviation of autoAB to plasminogen / angiostatin (X 2 (1) =6.75;VKramer = 0.482, p = 0.009, Fisher's exact test = 0.05). Violation CVR in response to the multidirectional FSS metabolic and myogenic orientation in carotid and vertebral-basilar basins associated with the rejection of аverage individual level of immunoreactivity (X 2 (1) = 6.39; VKramer = 0.478, p = 0.011, Fisher's exact test = 0.026) and violation of autoAB to plasminogen / angiostatin (X 2 (1) = 4.77; VKramer = 0.406, p = 0.029). Conclusions. It was found that the ability CVR is in conjunction with a violation of the structural and functional integrity of the cardiovascular system, such as endothelial function directed to the regulation of the structural integrity of the vascular system, hemostasis and inflammation.