Abstract
Whipple’s disease is a rare multiorgan disease caused by an intracellular bacterium, Tropheryma whipplei(1). It is often characterized by nonspecific symptoms, such as fatigue, weight loss, fever, diarrhea, and polyarthralgias (2). The majority of patients with Whipple’s disease have involvement of the proximal intestine and mesenteric lymph nodes (3). Whipple’s disease is usually diagnosed using light microscopy to demonstrate massive infiltration of foamy macrophages that are strongly positive for the periodic acid-Schiff (PAS) stain in the lamina propria of an intestinal biopsy sample (3).
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