Immunohistochemistry study of pentoxifylline in the treatment of alopecia induced by cyclophosphamide in male rats

Abstract

Objective: Hair is the human body's major esthetic display component, especially in cultural and social interactions. Alopecia starts to be diagnosed medically at a level that about 25 to 40 percent of the person's hair is dropped. Throughout this research, the potency of topical pentoxifylline in stimulating regrowth in hair loss caused by cyclophosphamide was established. Methods: The study was performed by treatment with pentoxifylline topically in male Swiss albino rats. The animals divided into seven groups with six animals in each group. To induce alopecia Cyclophosphamide used at a dose of (125 mg/kg) intraperitoneal. The animals in this study have hair clippered at day one and at day six of experiment to induce entrance of hair follicles into anagen phase. All groups injected cyclophosphamide at day 15 of experiment except control group injected only distilled water. The treatment period was fourteen days for rats used in this study. All animals in groups of study sacrificed at day 29 of experiment. Results: Hair weight assessment showed improvement in hair growth with increasing pentoxifylline concentration in groups. Strong follicular proliferation was demonstrated by histopathology and gross morphological observations of hair growth in shaved areas.