Abstract
Changes of the intrarenal localization and concentration of renin in comparison to those of angiotensin II (ANG II) are shown under various conditions of stimulation and inhibition of the renin-angiotensin-system. Evidence is presented that ANG II which is detectable by immunocytochemical methods in epitheloid cells is formed locally within the kidney either intra- or extracellularly. ANG II-like activity was found not only in the epitheloid cells of the JGA, but also further upstream in non specialized, "plain" smooth muscle cells of the renal arterial tree and in the medial muscle cells of resistance vessels in other organs and tissues. This ANG II-like activity of resistance vessels is increased in spontaneously hypertensive rats suggesting a possible role in the long-term regulation of blood pressure.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Clinical and experimental hypertension. Part A, Theory and practice
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
