Abstract
The existence of two classes of intracellular retinoid-binding proteins, the cellular retinol-binding proteins (CRBP I and II) and cellular retinoic acid-binding proteins (CRABP I and II), have been known for a long time (). Yet, the precise roles of these proteins in retinoid physiology remains poorly defined. One of the major reasons for this has been the difficulties of generating high-quality antibodies to facilitate their detection in tissues and cells by immunohistochemical techniques.
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