Abstract
Objective To quantify the number of mature and immature dendritic cells (DCs) in oral papilloma (OP) and tonsillar carcinoma (TC) and its relation to human papilloma virus. Study Design A total of 21 cases of OP, 21 cases of TC, and 12 control cases of healthy oral mucosa samples were used. Immunohistochemical reactions against CD1 and CD83 were performed to identify immature and mature DCs respectively. Detection of the virus was made with p16 antibody. Quantitative and semiquantitative analysis using Image J 1.45 s software was applied for determination of immunopositivity. Results In the epithelium, CD1 a + DCs were significantly decreased in TC compared with morphologically normal tissue (P = .02) and OP (P = .005). In the connective compartment, CD83 + DCs were significantly decreased in OP and TC compared with normal connective tissue (P .05). Conclusion The population of DCs is not influenced by the positivity of p16 but may contribute to the etiopathogenesis of OP and TC.
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