Abstract
Aim – to study the features of MUC1, MUC2, MUC5AC, Cdx-2 immunohistochemical expression in hyperplastic polyps and intestinal-type gastric adenocarcinoma, and their relationships with the proliferation and apoptosis markers expression levels, EGFR and HER-2/neu growth receptors. Materials and м ethods. Pathomorphological and immunohistochemical studies of hyperplastic polyps from 30 patients (the age ranged from 52 to 73 years) and intestinal-type gastric adenocarcinoma from 30 patients (the age ranged from 49 to 86 years) were carried out. Results. It has been established that the gastric hyperplastic polyps are characterized by the high MUC5AC expression level, the moderate MUC1expression level, as well as the low MUC2 and Cdx-2 expression levels. The tumor cells of the intestinal-type gastric adenocarcinoma express gastric mucins less often, and are characterized by the moderate expression levels of the examined markers. In doing so, the carcinoma is characterized by the inverse correlations between gastric and intestinal mucins expression levels, and also by the correlations between the mucins markers expression levels and the histological grade of the tumor. It has been found, that the decrease in the MUC1 expression level by the tumor cells is associated with the increase in their proliferative level, while the decrease in the MUC1 and MUC5AC expression levels – with the decrease in their apoptosis level and also with the increase in the ErbB family growth receptors expression levels by the tumor cells. In addition, the increase in MUC2 expression level is associated with the decrease in apoptosis level, while the increase in the MUC2 and Cdx-2 expression levels – with the increase in EGFR expression level. Conclusions. There are close relationships between MUC1, MUC2, MUC5AC, Cdx-2 immunohistochemical expression levels and the levels of proliferative and apoptotic activity of intestinal-type gastric adenocarcinoma tumor cells, and also their expression of ErbB growth receptors.
Highlights
It has been established that the gastric hyperplastic polyps are characterized by the high MUC5AC expression level, the moderate MUC1expression level, as well as the low MUC2 and Cdx-2 expression levels
The carcinoma is characterized by the inverse correlations between gastric and intestinal mucins expression levels, and by the correlations between the mucins markers expression levels and the histological grade of the tumor
That the decrease in the MUC1 expression level by the tumor cells is associated with the increase in their proliferative level, while the decrease in the MUC1 and MUC5AC expression levels – with the decrease in their apoptosis level and with the increase in the ErbB family growth receptors expression levels by the tumor cells
Summary
Особенности иммуногистохимической экспрессии MUC1, MUC2, MUC5AC, Cdx-2 и их значение в гиперпластических полипах и в аденокарциноме желудка кишечного типа. Цель работы – изучить особенности иммуногистохимической экспрессии MUC1, MUC2, MUC5AC, Cdx-2 в гиперпластических полипах и аденокарциноме желудка кишечного типа, а также их взаимосвязь с уровнями экспрессии маркеров пролиферации и апоптоза, ростовых рецепторов EGFR и HER-2/neu. Существует тесная взаимосвязь между уровнями иммуногистохимической экспрессии MUC1, MUC2, MUC5AC, Cdx-2 и уровнями пролиферативной, апоптотической активности опухолевых клеток аденокарциномы желудка кишечного типа, а также экспрессией ими ростовых рецепторов ErbB. Мета роботи – вивчити особливості імуногістохімічної експресії MUC1, MUC2, MUC5AC, Cdx-2 в гіперпластичних поліпах та аденокарциномі шлунка кишкового типу, а також їхній взаємозв’язок із рівнями експресії маркерів проліферації та апоптозу, ростових рецепторів EGFR і HER-2/neu. Наявний тісний взаємозв’язок між рівнями імуногістохімічної експресії MUC1, MUC2, MUC5AC, Cdx-2 та рівнями проліферативної, апоптотичної активності пухлинних клітин аденокарциноми шлунка кишкового типу, а також експресією ними ростових рецепторів ErbB.
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