Abstract
We report the findings of immunohistochemical stains in conjunctival mucosa- associated lymphoid tissue (MALT) lymphoma in a 52-year-old woman. The patient was presented with salmon-color patch on the bulbar conjunctiva of both eyes for two months. Extensive excision of the lesion through the conjunctiva was performed. The pathological findings and immunohistochemical stains revealed the tumor cells are positive for Bcl-2, CD20, kappa monoclonality, and surface intercellular adhesion molecule-1 (ICAM-1), but negative for CD3, CD5, CD23, and cyclin D1. Bcl-2 is an apoptosis inhibitor. Anti-CD20 immunostaining confirms the cells within the lymphoepithelium as pre-B cell and mature B cells but not plasma cells. The expression of ICAM-1 is variable and depends on the differentiation stage of the malignant B-cell in B-cell-derived non-Hodgkin's lymphoma (NHL). Systemic examinations were all within normal limits. And, the patient was given 50 mg of cyclophosphamide orally, three times a day for twelve weeks. During the period, the patient was followed clinically, with slit lamp examination, for evidence of tumor disappearance or recurrence. Immunohistochemical studies play an important role in determing the diagnosis of conjunctival mucosa-associated lymphoid tissue (MALT) lymphoma.
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