Abstract
Forssman (Fo) glycolipid antigen, as detected by a monoclonal antibody (mAb), is expressedby a subpopulation of murine macrophages in the spleen and peripheral lymph nodes. The histological distribution of Fo antigen in spleen and lymph nodes was studied by immuno-staining of cryosections, and was compared with the staining pattern of four other mAbs known to recognize macrophage subpopulations: F4/80, Mac-1, MOMA-1, and ERTR-9. Fo + macrophages were found exclusively in the red pulp of the spleen and the medulla of inguinal and axial lymph nodes. Macrophages in the other lymphoid organs were Fo -. Besides macrophages, reticular cells in T-dependent areas of spleen and lymph nodes were Fo +. Attempts to grow colonies of Fo + macrophages from either bone marrow or spleen precursors were negative. While the usual number of F4/80 + colonies was obtained, only a few, small clusters of Fo + macrophages were formed, which speaks against an early commitment of precursors to express Fo.
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