Abstract
We examined the presence of epidermal growth factor (EGF) and transforming growth factor α (TGFα) in the prostate (ventral, lateral, dorsal lobes), coagulating gland and seminal vesicle of Fisher 344 adult male rats by immunohistochemical and radioimmunoassay methods. Immunohis-tochemically demonstrable EGF was localized in the luminal secretion only of the dorsal lobe of the prostate. Reactive TGFα was localized in the lateral lobe (100% of epithelial cells), dorsal lobe (about 40% of the epithelial cells) and seminal vesicle (100% of epithelial cells), but not in the coagulating gland or ventral lobe of the prostate. Radioimmunoassay also demonstrated a measurable amount of TGFα in the lateral lobe (194 pg./gm. wet weight) and seminal vesicle (74 pg./gm.). Assayable EGF was demonstrated at much higher levels in all prostate lobes (ranging from 1.2 μg./gm. wet weight in the ventral lobe to 26.4 μg./gm. in the dorsal lobe) and the seminal vesicle (0.9 μg./gm.). This is the first report describing the presence of immunoreactive TGFα and EGF in the male accessory sex organs.
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