Abstract
ABSTRACTPurpose:Glucose is a major energy resource for tumor cell survival and growth, and its influx into cells is mainly carried out by facilitative glucose transporters (GLUTs). Sodium - dependent glucose transporters (SGLTs) have been highlighted as playing important roles in diabetic treatment. However, their potential roles in cancer remain unclear. We examined expression patterns of SGLTs in tumor tissues together with conventional pathological variables to determine prognostic significance in patients with renal cell carcinoma (RCC).Materials and Methods:Nephrectomy specimens were obtained from 68 patients. GLUT - 1, - 2 and SGLT - 1, - 2 expression in tumor and adjacent normal tissues were analyzed by immunohistochemical staining, and intensity was quantified using an image analyzer.Results:The four glucose transporters evaluated were broadly distributed in tumor tissues as well as throughout the normal parenchyma. There was no significant correlation between transporter expression and conventional pathological variables. However, increased SGLT - 2 expression was significantly associated with shorter overall survival (p < 0.01), regardless of metastatic status.Conclusions:We propose possible prognostic significance of SGLT - 2 expression in human RCC. Given that glucose is a major energy resource for tumor cells and that glucose transport is largely mediated by SGLT, SGLT - 2 may serve as a possible therapeutic target in RCC.
Highlights
Glucose is a major energy resource for tumor cell survival and growth, and its influx into cells is mainly carried out by facilitative glucose transporters (GLUTs)
We investigated the correlation between pathological parameters and expression of glucose transporters including GLUT - 1, GLUT - 2, Sodium - dependent glucose transporters (SGLTs) - 1, and SGLT - 2, and their prognostic implications in human renal cell carcinoma (RCC)
GLUT - 1 staining in tumor tissue was strong, while GLUT - 2 and SGLT - 1 staining was weak in the majority of cases
Summary
Glucose is a major energy resource for tumor cell survival and growth, and its influx into cells is mainly carried out by facilitative glucose transporters (GLUTs). We examined expression patterns of SGLTs in tumor tissues together with conventional pathological variables to determine prognostic significance in patients with renal cell carcinoma (RCC). Tumor cells cover their energy requirements by anaerobic glycolysis known as the Warburg effect, which demands high glucose levels To survive in such a hostile microenviibju | Sodium - dependent glucose transporter - 2 in RCC sodium - dependent glucose transporter ronment, tumor cells up - regulate expression of membrane glucose transporters, such as glucose transporters (GLUTs) and sodium - dependent glucose transporters (SGLTs) [3]. We investigated the correlation between pathological parameters and expression of glucose transporters including GLUT - 1, GLUT - 2, SGLT - 1, and SGLT - 2, and their prognostic implications in human RCC
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