Abstract
Objective: The X-linked inhibitor of apoptosis protein (XIAP) immunohistochemical expression was employed to assess the anti-apoptotic activity of mucoepidermoid carcinoma (MEC) in relation to different clinicopathological variables to understand if XIAP immunoexpression could reflect the histologic grade and the biologic activity and prognosis in MEC patients.
 Materials and Methods: A retrospective study was accomplished on 16 MEC cases. The worked MEC cases involved the three histologic grades, low, intermediate, and high. Assessement of XIAP immunoexpression was made in relation to different clinicopathological parameters. The analysis of data was done by Pearson`s Chi-square test. Pearson correlation co-efficiency test was used to test the association between the different variables. The P‐value <0.05 was considered to be statistically significant.
 Results: There were statistically significant differences in XIAP immunoexpression in relation to the following parameters; the TNM clinical stage (P=0.036), and the histologic grade (P=0.008). Conversely, the immunoexpression of XIAP was not significantly correlated with patients’ age (P=0.141), patients` gender (P= 0.471), and the anatomical site of the tumor (P=0.827) in MEC cases.
 Conclusion: The immunoexpression of XIAP correlates with histologic grading of MEC. Additionally, XIAP immunoexpression reflects the clinical and biological behavior of MEC.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
