Abstract
Hepatocellular carcinoma (HCC) is the fifth most common neoplasm, the major cause of death in patients with cirrhosis, and the third most common cause of cancer-related death in the world. In Egypt, hepatocellular carcinoma (HCC) is the second most common cancer in men and the 6th most common cancers in women. Egypt has the highest prevalence of HCV in the world and the prevalence of HCC is increasing in the last years. Nowadays, HCV infection and its complications are among the leading public health challenges in Egypt with 13.8% of population infected and, in these patients, the risk of HCC is increased 17-fold. Glypican-3 (GPC3) is a member of heparin sulfate proteoglycan family which is linked to cell surface. It plays an important role in regulation of cell growth, differentiation, and migration. It is normally expressed in fetal liver and placenta but not in normal adult liver tissue. 8-Hydroxydeoxyguanosine (8-OHdG) is an oxidatively modified promutagenic DNA that is produced by oxygen radicals and is recognized as a useful marker in estimating DNA damage induced by oxidative stress. The present work is a retrospective, cross-sectional, study performed on 150 liver paraffin blocks that included 100 cases of chronic hepatitis C and 50 cases of hepatocellular carcinoma. These cases were collected from the Pathology Department. The 100 cases of chronic hepatitis C were graded into low grade chronic hepatitis (58) cases and high-grade chronic hepatitis (42) cases, 30 patients had cirrhosis, all in the high-grade group. The 50 cases of hepatocellular carcinoma (HCC) included 18 cases of well-differentiated HCC (grade I), 22 cases of moderately differentiated HCC (grade II) and 10 cases of poorly differentiated HCC (grade III). Among 50 cases of HCC, 44 cases showed cirrhosis in the non-neoplastic liver tissue. There was a statistically significant difference in 8-OHdG index between chronic hepatitis and hepatocellular carcinoma (P = 0.006).
Highlights
Hepatocellular carcinoma (HCC) accounts for > 5% of all human cancers and for 80% - 90% of primary liver cancers
8-Hydroxydeoxyguanosine (8-OHdG) is an oxidatively modified promutagenic DNA that is produced by oxygen radicals and is recognized as a useful marker in estimating DNA damage induced by oxidative stress and in patients with chronic hepatitis C, increased 8-OHdG in DNA extracted from liver tissue was reported [10]
This work is a retrospective, cross-sectional study carried out on 150 liver paraffin blocks that were previously diagnosed as chronic hepatitis C (100 cases) and hepatocellular carcinoma (50 cases), collected from the Pathology Department, Faculty of Medicine, in the period from October 2019 to January 2020
Summary
Hepatocellular carcinoma (HCC) accounts for > 5% of all human cancers and for 80% - 90% of primary liver cancers. It is a major health problem worldwide being the fifth most common malignancy in men, the eighth in women and the third most common cause of cancer-related death in the world [1]. HCC incidence has increased sharply over recent decades and has been attributed to chronic hepatitis C virus (HCV) infection. Chronic HCV infection, is a major risk factor for HCC development. Each year, 4-5% of patients with chronic hepatitis C develop HCC. HCV infection increases the risk for HCC development by an estimated 17-fold compared to healthy individual [2]
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