Immunohistochemical expression of PDL1 in laryngeal carcinoma in relation to P53 and ki67 proliferative index

Abstract

Squamous cell carcinoma of larynx is one of the most common malignant neoplasms of the head and neck. Carcinoma of the larynx represents 2.2% of all cancers in men and 0.4% in women, with predilection of old aged men of more than 50 years rather than women. Smoking is the main risk factor. Alcohol, nutritional factors and virus as Human papillomavirus (HPV) play a role in the pathogenesis of laryngeal carcinoma. Programmed death-ligand (PDL1) is the new introduced marker that be considered as treatment target nowadays in addition to its prognostic application. Aims of study: This study was designed to assess the predictive the role of PDL1 in laryngeal squamous cell carcinoma in comparison with other prognostic markers (P53 and Ki-67).Results: The current study revealed that PDL1 expression was reported in about 20 % of laryngeal squamous cell carcinoma and 10% in premalignant, while it was negative in benign laryngeal lesions. Others markers; P53 protein was shown to be positive in around 42.5 percent of laryngeal squamous cell carcinomas, 40 percent of premalignant laryngeal lesions, and about 12 percent of benign laryngeal lesions.