Abstract
ObjectivesPaired box protein-8 (PAX-8) immunohistochemical expression can be used as a diagnostic marker for epithelial cells tumors. This study aimed at investigating the immunohistochemical expression of PAX-8 among Sudanese females diagnosed with cervical, endometrial, and ovarian cancers between December 2017 and May 2019 by studying their Formalin-fixed paraffin embedded blocks.ResultsSixty patients diagnosed with female reproductive tract cancers were included who aged 58.7 ± 6.9 years (range, 43—71). Cervix was the most common cancer site in 51/60 (85%) patients. Regarding cancer stage, there was 17 (28%) and 14 (23%) of the study population had stage 3B and 2B, respectively. The histopathological diagnosis included 20 (44%), 13 (29%), and 12 (27%) poorly, moderately, and well differentiated cervical squamous cell carcinoma (SCC) as well as 11 (73%), 2 (13%), 1 (7%), and 1 (7%) endometrial adenocarcinoma, metastatic adenocarcinoma, endocervical adenocarcinoma, and ovarian mucinous cyst adenocarcinoma, respectively. PAX-8 was positively expressed in 9 endometrial adenocarcinoma, 1 endocervical adenocarcinoma and 1 ovarian mucinous cyst adenocarcinoma, 2 poorly, and 1 moderately differentiated SCC. All patients diagnosed with well differentiated SCC and metastatic adenocarcinoma showed no expression of PAX-8. A statistically significant was seen for PAX-8 expression and the different histopathological diagnosis, P value < 0.001.
Highlights
Paired box protein-8 (PAX-8) is a member of the family paired box proteins (PAXs) [1, 2]
This study aimed at investigating the immunohistochemical expression of PAX-8 among Sudanese females diagnosed with cervical, endometrial, and ovarian carcinomas
Previous studies on the immunohistochemical expression of PAX-8 in the normal female reproductive tract showed that PAX-8 was expressed in the endometrial, endocervical, and ovarian epithelial cells, as well as in non-ciliated epithelial cells of the fallopian tubes [17, 20, 28, 29]
Summary
Paired box protein-8 (PAX-8) is a member of the family paired box proteins (PAXs) [1, 2]. PAX-8 is a transcription factor that regulates organs development during the embryonic period, as well as to maintain normal cellular functions in some cells after birth [6, 7]. In a healthy female reproductive tract, PAX-8 shown to be overexpressed in the epithelial cells of the endocervix and the endometrium [14,15,16]. For the ovarian carcinomas, PAX-8 was under expressed [24]. Considering that, few studies have investigated the immunohistochemical expression of PAX-8 in carcinomas of the endometrium and uterine cervix in the different parts of the world but none from Sudan yet [17, 24,25,26,27]. This study aimed at investigating the immunohistochemical expression of PAX-8 among Sudanese females diagnosed with cervical, endometrial, and ovarian carcinomas
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
