Abstract
BACKGROUND: Vascular tumors are a heterogeneous group of diseases with biological behavior ranging from a hamartomatous growth to frank malignant. The pathophysiology of lymphangioma, vascular malformation and hemangioma is interconnected, blood vessels known to be the site of origin of hamartomas, venous malformations and some neoplasms as benign, tumor-like growth of vessels (hemangiomas). Angiogenesis is the process of formation of new blood vessels from an existing structure.
 Aims of study Assessment of angiogenic potential in benign vascular lesions (hemangioma, lymphangioma and lobular capillary hemangioma) of head and neck region.
 Materials and Methods: Twenty-two formalin-fixed paraffin-embedded tissue blocks of Hemangioma/vascular malformation, thirty of lobular capillary hemangioma and another twenty of lymphangioma to be stained with Endothelial cell-Specific Molecule-1 (ESM-1) monoclonal antibody. 
 Results: Microvessel density expressed by Endothelial cell-Specific Molecule-1 (ESM-1) immunomarker was found in all cases with mean density of (37.44±23.16) for lobular capillary hemangioma and (25.02±13.89) for hemangioma and (6.34±3.52) for lymphangioma. According to post hoc test ESM-1 marker expression showed a high significant difference between (hemangioma and lymphangioma=0.001), (lymphangioma, pyogenic granuloma=0.000), and it was significantly different between (hemangioma, pyogenic granuloma=0.011)
 Conclusions: The obvious capillary growth in lobular capillary hemangioma revealed that lobular capillary hemangioma showed the highest activity of angiogenic potential in comparison to hemangioma and lymphangioma.
Highlights
IntroductionThe pathophysiology of vascular malformation, hemangioma and lymphangioma is interrelated, blood vessels known to be the site of origin of venous malformations, hamartomas and some neoplasms as benign, tumor-like growth of vessels (hemangiomas)
Vascular system is a highly heterogeneous and non-identical organ system, to make a judgment whether the entire lesion is composed of only venous component or whether there is a lymphatic channels cannot be easy(1).To increase the flow of blood to ischemic tissue the human body grows new blood vessels from an existing structure, the process of formation of new blood vessels termed angiogenesis (2).Vascular development starts by the gathering of a vessel plexus from single cell precursors, adjustment undergoes to this plexus by sprouting growth and remodeling, followed by recruitment of vessels into target tissues, according to the specific needs of the tissue, new vessels differentiate. (3)(1) Department of Oral Diagnosis, College of Dentistry, Al-Mustansyria University. (2) Professor
1 was applied to hemangioma, pyogenic granuloma and lymphangioma, where the endothelial cells of blood vessel were stained with brown coloration as seen in (Figures 1,2, 3,4and 5)
Summary
The pathophysiology of vascular malformation, hemangioma and lymphangioma is interrelated, blood vessels known to be the site of origin of venous malformations, hamartomas and some neoplasms as benign, tumor-like growth of vessels (hemangiomas). Aims of study Assessment of angiogenic potential in benign vascular lesions (hemangioma, lymphangioma and lobular capillary hemangioma) of head and neck region. Materials and Methods: Twenty formalin-fixed paraffin-embedded tissue blocks of lymphangioma, thirty of lobular capillary hemangioma and another twenty-two of Hemangioma/vascular malformation to be stained with ndothelial cell-Specific Molecule-1 (ESM-1) monoclonal antibody. Results: Microvessel density expressed by Endothelial cell-Specific Molecule-1 (ESM-1) immunomarker was found in all cases with mean density of (25.02±13.89) for hemangioma and (37.44±23.16) for lobular capillary hemangioma and (6.34±3.52) for lymphangioma. Along with post hoc test ESM-1 marker expression showed a high significant difference between (lymphangioma and hemangioma =0.001), (lymphangioma, pyogenic granuloma=0.000), and it was significantly different between (hemangioma, pyogenic granuloma=0.011) Conclusions: The obvious capillary growth in lobular capillary hemangioma revealed that lobular capillary hemangioma showed the highest activity of angiogenic potential in comparison to hemangioma and lymphangioma
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