Abstract
This study investigated the immunohistochemical expression of cytokeratins (CK) 5/6, 7, 8, 10, 13, 14, 18, and 19 in five cases of central odontogenic fibromas (COF), nine peripheral odontogenic fibromas (POF), and three dental follicle specimens. Study Design: Paraffin-embedded sections were obtained for the immunohistochemical evaluation of CK monoclonal antibodies. Results: CK 14 expression was positive in the epithelial islands of all cases. In four OF cases (28.57%) a weak positivity to CK 19 was observed in some central stellate cells (three POF and one COF). Of these four cases, three were WHO type and one simple type. Strong expression of CK 7 was detected in some central stellate cells and peripheral columnar cells of three cases of POF (21.43%). Conclusion: CK expression in OFs suggested a variable degree of epithelium maturation, demonstrating a possible difference in COF and POF origin.
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