Abstract
Aim Bcl-2 is a proto-oncogene known to be a negative regulator of apoptosis which confers prolonged cell survival and possibly contributes to tumorigenesis. A number of studies have been carried out to estimate and analyse its expression in renal tumours but the results have been conflicting. The aim of this study was to determine the expression and intensity of Bcl-2 in renal cell carcinomas (RCCs). Methods Fifty-nine cases of formalin-fixed, paraffin-embedded tissue samples of RCCs were studied immunohistochemically for bcl-2 (monoclonal mouse antihuman bcl-2 oncoprotein antibody, clone 124;DakoCytomation) expression and intensity of staining (score 0–4). Results The results showed that 55 cases of clear cell RCC were negative for bcl-2. However, one case each of papillary (2+) and chromophobe RCC (4+) and two cases of RCC with sarcomatoid transformation (3+ and 4+, respectively) showed positivity. Discussion Clear cell RCC is not associated with expression of bcl-2 except for the papillary and chromophobe variants and RCC with sarcomatoid transformation.
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