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Abstract
Background Oral malignancy includes a group of neoplasms affecting any district of the oral cavity, salivary glands, and pharyngeal regions. Notwithstanding, this term has a tendency to be utilized conversely with oral squamous cell carcinoma (OSCC), which represents the most incessant of every oral neoplasm. It is evaluated that a greater than of 90% of oral neoplasm are OSCC malignancies. The Bcl-2 protein is the encoding result of Bcl-2 proto-oncogene. The overexpression of Bcl-2 protein assumes an imperative part in apoptosis protection in many tumors, including head and neck squamous cell carcinoma. Aim/objectives This study was conducted to scope and find out the possible role of Bcl-2 in the biological behavior of OSCC. Methods A total of 20 OSCC cases were immunohistochemically examined for expression of Bcl-2. Results and conclusions There was significant difference among grades of OSCC regarding Bcl-2 expression. A significant correlation between Bcl-2 expression and clinical staging, nodal infiltration, as well as distant metastasis was observed. We concluded that Bcl-2 may be used as a prognostic factor for OSCC and may aid in decisions on cancer diagnosis and therapy.
Published Version
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