Abstract
Four testicular sex cord stromal tumors (3 Leydig cell tumors and 1 Sertoli-Leydig cell tumor) and the Sertoli and Leydig cells of 10 nonneoplastic testes were studied for their immunohistochemical reactivity to intermediate filaments. Low molecular weight cytokeratin positivity was present in the Sertoli cell component of the Sertoli-Leydig cell tumor and in Sertoli cells in atrophic seminiferous tubules of 4 of 10 nonneoplastic testes. Vimentin reactivity was present in the majority of Sertoli and Leydig cells in neoplastic and nonneoplastic testes. There was uniformly no reactivity for epithelial membrane antigen, carcinoembryonic antigen, and S-100 protein in either cell type. Our studies suggest that expression of intermediate filament may distinguish testicular Sertoli from Leydig cells and neoplasms derived from them. (The J Histotechnol 17:119, 1994)
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