Abstract
The cellular distribution of the histone H1 0/H5 variant has been examined immunohistochemically in various tissues of adult Xenopus laevis, using monoclonal antibodies against this variant that was isolated from erythrocyte nuclei. The H1 0/H5 variant appears not to be erythrocyte-specific and appears to be present in all cell types of liver, stomach, and skin. In contrast, in oocyte nuclei the H1 0/H5 variant cannot be detected, whereas they do contain H1; the nuclei of spermatogenic cells contain the H1 0/H5 variant, but probably less than the somatic cells. In Xenopus no H1 0 variant distinct from H5 seems to occur and the H1 0/H5 variant apparently may perform a functional role related to mammalian H1 0.
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