Abstract
Twenty one cases of colorectal adenocarcinoma and six of adenoma have been studied using the monoclonal antibody Ki-67 which recognizes a nuclear antigen expressed by proliferating cells (PC). The quantitative evaluation of the stained nuclei showed that PC were more numerous in carcinomas than in adenomas although the difference did not reach a significant level. In each tumour, heterogeneity was noted. Furthermore, the superficial areas of both carcinomas and adenomas contained a greater number of PC than the deep. No difference was noticed in the various types and grades of differentiation for carcinomas. This preliminary report, compared with the only previous study of Shepherd et al. (1988) outlines the interest of the monoclonal antibody Ki-67 in the evaluation of growth fractions in colorectal tumours.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Virchows Archiv A Pathological Anatomy and Histopathology
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
